Operation of Milli-Q-Water System

1. Objective

To lay down a procedure for Operation of Millipore Water Purification System

• Scope

This SOP is applicable in Quality Control for operation of Millipore water purification system.

• Responsibility

QC Chemist                : Follow the procedure and maintain record as applicable.   

• Accountability

Head Quality Control  : System Compliance

• Procedure:                                                                                                                  
  • Use Milli-Q water for all type of analysis purpose like Assay, standard solution, test solution for HPLC, UV and preparation of other standards etc.
  • To check the Milli Q Water quality select menu, then select Water quality and at last select Milli Q Water quality. Display shall give current information of Milli Q Water like TOC, resistivity, temperature. Check pH, conductivity and TOC on daily basis before use.
  • Check the pH of Milli-Q water offline and record in Annexure-I. pH should be between 5.0 to 7.0
  • Record the conductivity and TOC of Milli-Q water online and record in Annexure-I. The limit for conductivity should be NMT 1.3µs/cm and TOC should be NMT 500 ppb.
  • Calibration of pH sensor, conductivity sensor and TOC sensor shall be done by outside vendor on annual basis.
  • Instrument Panel:
    • Details of instrument panel is as below-